Random blood glucose was positively correlated with WC in a Nigerian population, while another study correlated FBG positively with WC in Iran. Thirty percent of overweight persons (BMI > 23 kg/m 2) and 25% of obese persons (BMI > 25 kg/m 2) were diabetic and a positive correlation was found between the BMI and WC. Two hundred and four obese persons of both sexes from west India were assessed to determine the incidence of type 2 diabetes mellitus among them and to determine if the fasting blood glucose (FBG) levels had any correlation with the body mass index (BMI) and waist circumference (WC). A study on 10,913 healthy persons, who were arbitrarily categorized based on their FPG levels as 5 groups (i.e., 50–79, 80–84, 85–89, 90–94, and 95–99 mg/dL) were followed up for an average of 4.3 years showed that participants who had fasting glucose levels in the high normal range (95–99 mg/dL) had an increased risk of cardiovascular disease when compared with other four groups. These factors include the BMI, central obesity and also raised fasting blood glucose levels. Multiple factors contribute to the risk of persons who are obese developing cardiovascular and other diseases. These results suggest the importance of understanding the association between the body weight and lipid profile in persons who are obese to consider ways for management. Apart from this epidemiological evidence a longitudinal study on young adults (aged between 19 and 32 years) who were overweight, hypertensive and had dyslipidemia had the same risk factors (i.e., being overweight, with elevated blood pressure levels and abnormal serum lipid profile values) in childhood. Autopsy reports on adolescents who died in accidents found an association between fatty streaks in the coronary arteries and aorta with abnormal trends in the lipid profile, blood pressure and body weight prior to death. Įvidence from epidemiological studies suggests that the relationship between obesity and developing cardiovascular disease begins early in life. Central adiposity is considered particularly dangerous as visceral fat is known to secrete pro-inflammatory substances and is associated with an increase in dyslipidemia and cardiovascular disease. Obesity has increased worldwide with an increase in the incidence of associated diseases especially type 2 diabetes mellitus (DM). Among the healthy participants 34.2% had pre-diabetes and 13.6% had diabetes. A significant positive correlation of FBG and waist circumference was also observed. Total cholesterol/HDL ratio was positively correlated with waist circumference and negatively correlated with body fat. HDL cholesterol was significantly negatively correlated with waist circumference and positively correlated with body fat. Triglycerides showed a significant negative correlation with BMI and body fat. Resultsīased on a linear regression analysis triglycerides acted as a significant predictor for body fat. Statistical significance (α) was set at 0.05. The participants were assessed for (i) BMI and WC, (ii) body fat, (iii) fasting serum lipid profile and (iv) FBG. There were 1140 participants of both sexes (female:male 697:443 group mean age 44.0 ± 10.8 years BMI ≥ 25 kg/m 2) from four regions of India. The present study was conducted on healthy obese persons to determine: (i) the association between total cholesterol, triglycerides, HDL cholesterol, total cholesterol/HDL ratio and fasting blood glucose (FBG) with (a) BMI, (b) waist circumference (WC) and (c) body fat and (ii) the presence of undiagnosed type 2 diabetes (based on fasting blood glucose) in the participants.
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